Robotic systems for chemical synthesis are growing in popularity but can be difficult to run and maintain because of the lack of a standard operating system or capacity for direct access to the literature through natural language processing. Here we show an extendable chemical execution architecture that can be populated by automatically reading the literature, leading to a universal autonomous workflow. The robotic synthesis code can be corrected in natural language without any programming knowledge and, because of the standard, is hardware independent. This chemical code can then be combined with a graph describing the hardware modules and compiled into platform-specific, low-level robotic instructions for execution. We showcase automated syntheses of 12 compounds from the literature, including the analgesic lidocaine, the Dess-Martin periodinane oxidation reagent, and the fluorinating agent AlkylFluor.

化学合成执行的概念表示

系统工作流

系统的架构和操作概述

合成阅读器的操作和性能概述

使用合成阅读器自动分析文献程序的硬件要求

化学计算机实现的合成的化学方案和相应的抽象化学过程。

A universal system for digitization and automaticexecution of the chemical synthesis literature