Robotic systems for synthetic chemistry are becoming more common, but they are expensive, fixed to a narrow set of reactions, and must be used within a complex laboratory environment. A portable system that could synthesize known molecules anywhere, on demand, and in a fully automated way, could revolutionize access to important molecules. Here we present a portable suitcase-sized chemical synthesis platform containing all the modules required for synthesis and purification. The system uses a chemical programming language coupled to a digital reactor generator to produce reactors and executable protocols based on text-based literature syntheses. Simultaneously, the platform generates a reaction pressure fingerprint, used to monitor processes within the reactors and remotely perform a protocol quality control. We demonstrate the system by synthesizing five small organic molecules, four oligopeptides and four oligonucleotides, in good yields and purities, with a total of 24,936 base steps executed over 329 h of platform runtime.

图1：紧凑型/便携式平台上进行的任何合成的示意图。

图2：a.反应操作：合成操作包含在定制的模块中。为了控制模块内的操作，需要执行一系列涉及电磁阀、压力传感器和微型泵的连续步骤。b,平台操作：任何化学合成所需的一般操作，包括溶剂和试剂的液体处理，以及反应器的加热和冷却。

图3：便携式平台的实际应用。

图4：利用该平台制备的5种不同API的合成方案。

图5利用压力曲线对硫酸苯乙肼的合成进行指纹识别和验证。

图6:平台合成寡肽和寡核苷酸的示意图。

An autonomous portable platform for universal chemical synthesis